Close Cooperation Research Articles

Hepatic recruitment of myeloid-derived suppressor cells upon liver injury promotes both liver regeneration and fibrosis

BackgroundThe liver regeneration is a highly complicated process depending on the close cooperations between the hepatocytes and non-parenchymal cells involving various inflammatory cells. Here, we explored the role of myeloid-derived suppressor cells (MDSCs) in the processes of liver regeneration and liver fibrosis after liver injury.MethodsWe established four liver injury models of mice including CCl4-induced liver injury model, bile duct ligation (BDL) model, concanavalin A (Con A)-induced hepatitis model, and lipopolysaccharide (LPS)-induced hepatitis model. The intrahepatic levels of MDSCs (CD11b+Gr-1+) after the liver injury were detected by flow cytometry. The effects of MDSCs on liver tissues were analyzed in the transwell co-culture system, in which the MDSCs cytokines including IL-10, VEGF, and TGF-β were measured by ELISA assay and followed by being blocked with specific antibodies.ResultsThe intrahepatic infiltrations of MDSCs with surface marker of CD11b+Gr-1+ remarkably increased after the establishment of four liver injury models. The blood served as the primary reservoir for hepatic recruitment of MDSCs during the liver injury, while the bone marrow appeared play a compensated role in increasing the number of MDSCs at the late stage of the inflammation. The recruited MDSCs in injured liver were mainly the M-MDSCs (CD11b+Ly6G−Ly6Chigh) featured by high expression levels of cytokines including IL-10, VEGF, and TGF-β. Co-culture of the liver tissues with MDSCs significantly promoted the proliferation of both hepatocytes and hepatic stellate cells (HSCs).ConclusionsThe dramatically and quickly infiltrated CD11b+Gr-1+ MDSCs in injured liver not only exerted pro-proliferative effects on hepatocytes, but also accounted for the activation of profibrotic HSCs.

Creation and Legal Status of a Specially Authorized Body of Non-Banking Financial Services

The article is devoted to the peculiarities of state regulation in the market of non-banking financial services. At the same time, attention was paid to the creation of a specially authorized state body in the form of the National Commission for Control of the Market of Non-Banking Financial Services. The purpose of the article is to reveal the legal status, the order of formation, and clarify the main principles of the National Commission's activity. Achieving the outlined goal became possible thanks to the use of a complex of methods of scientific knowledge, in particular, the dialectical method (for comprehensive knowledge of the nature of the National Commission for Control over the Market of Non-Banking Financial Services), the formal-legal method (for establishing the content of legal norms), the formal-logical method (for identification of shortcomings in national legal regulation), comparative legal method (for studying the experience of other countries and determining the prospects for implementing their principles of activity in the national legal field). It has been studied that the special status of the commission is that it ensures the stability of the entire non-banking financial system of Ukraine, establishing the requirements that such institutions must meet, namely requirements for: liquidity, solvency, capital, asset quality, risk level of operations, profitability. The work examines the relationship between the commission and the National Bank of Ukraine, their cooperation in the market, which consists in the development of regulatory and legal acts and their approval. The need for the National Bank of Ukraine to delegate its powers to the National Commission for Control of Non-Banking Financial Services in relation to: registration of market participants, licensing of non-bank financial institutions, determining the procedure for issuing and canceling a license, approving the terms of operation of such institutions. In view of this, a new model of state regulation on the market of non-banking financial services was proposed in the form of concentration of all control functions on the market in a single operationally independent regulator - the National Commission for Control of Non-Banking Financial Services, which is in close cooperation with the National Bank of Ukraine and by the National Securities and Stock Market Commission. Also, the article emphasizes that regulation by the National Commission for Control of the Market of Non-Banking Financial Services should be complemented by a system of self-regulating participants in the market, which are an additional tool to state regulation.

Listeria brain abscess: a therapeutically challenging rare presentation of listeriosis

We report a very rare case of Listeria multiple brain abscesses manifested as delirium, which represented diagnostic and therapeutic challenges overcome only by the close cooperation between Infectious Diseases and Neuroradiology, without which a satisfactory outcome would not be achieved.An elderly man presented with confusion and drowsiness with a background of type-II diabetes mellitus. Although computed tomography of the brain only showed frontal lobe oedema, contrast magnetic resonance (MR) imaging showed numerous irregular rim-enhancing lesions containing central diffusion restriction, suggesting multiple pyogenic cerebral abscesses of unclear aetiology. Thereafter, Listeria monocytogenes was isolated from blood cultures, suggesting this as the causative organism. Deemed unsuitable for neurosurgical drainage, the patient received medical management with a protracted course of antibiotics. This case was extremely challenging, due to 1) the impossibility of source control, 2) the small number of effective antibiotics available to treat this condition, and 3) the inevitable antibiotic side-effects, derived from long-term exposure. A successful outcome was only possible thanks to strict close multidisciplinary follow up, requiring frequent MR imaging and a judicious antibiotic choice, including monitoring of their side-effects. Due to the rarity of this condition, there is lack of guidance on its management, hence the importance of multidisciplinary involvement with very close imaging and antibiotic monitoring.

Pulp addiction? Perspectives of local regime actors on the development of the growing pulp industry in Uruguay

The pulp and paper industry is one of the largest industries in the world. The main actors are a few multi-national enterprises operating in global markets. The industry is increasingly moving its production to the Global South, which alters global pulp value chains and the national socio-technical regimes of those countries. Additionally, the sustainability paradigm and transition to bioeconomy are challenging the pulp and paper industry of today. We conducted semi-structured expert interviews, analyzed, and interpreted the findings through the multi-level perspective framework. The study aims to advance knowledge on how the local regime actors inside the pulp regime perceive the development of the Uruguayan pulp industry since the MNEs established operations in Uruguay until 2018. Our findings suggest that local regime actors see that the Uruguayan pulp industry regime and its' development is highly influenced by multinational enterprises and the way they organized their global value chains. Uruguay's role in the global pulp industry value chain remains as a material resource provider, which has not improved the innovation capacity of the country particularly. The interviewees however feel that this is a key issue to develop in the country. Thus, we suggest that a transition to a sustainable bioeconomy in Uruguay would require steps forward in the immaterial resource base with closer cooperation between the industrial actors, the national research and education actors, and local small and medium-sized enterprises. In large-scale Global North–Global South investments a true collaboration between the multi-national enterprises and local regime actors is crucial for reaching a strongly sustainable bioeconomy.

Dogs understand the role of a human partner in a cooperative task

Humans are exceptionally flexible in cooperation, partly due to our ability to recognize the roles of cooperative partners. While some non-human animals understand the need for a partner in such interactions, it is unclear whether they grasp the consequences of their partner’s actions and adjust accordingly. Previous studies utilizing economic games with non-human animals yielded mixed results. We investigated dogs, known for their close cooperation with humans, in a stag hunt game. Dogs could cooperate for better rewards or defect for lower ones, while their human partners would either cooperate, never cooperate, or act randomly. We control for attraction to food, side bias, and local enhancement. Dogs were more likely to coordinate with their partners when it led to better rewards, suggesting that they understood their partner’s actions. By highlighting this cognitive skill in dogs, we advance our knowledge of the intricate mechanisms driving cooperative behavior in non-human animals.

Experience of Russian-Chinese industrial cooperation on the construction of the Moscow metro

The commissioning of the Big Circle Line in Moscow, some sections of which were laid jointly with Chinese underground builders, provided the first experience of interaction with foreign construction contractors on the Moscow Metro. The paper investigates this experience which is of value for the development of such works in the future. The analysis was carried out on the basis of scientific and technical documentation on certain facilities, the progress and results of construction and installation works, and information on other events. The paper describes the facilities where construction and installation works were carried out by joint efforts and shows the peculiarities of interaction between Russian and foreign (Chinese) metro builders on a number of sections of the Big Circle Line of the Moscow Metro. The achieved results are demonstrated by the example of individual underground stations. The study reveals the peculiarities of material and technical support of works on the sections constructed by Chinese construction contractors. The mutual exchange of experience, technologies, and work management practices along with the application of various tunnel boring machines from both countries (Russia and the PRC) has yielded fruitful results, demonstrated the possibility and efficiency of the direct engagement of foreign tunnel builders at Russian sites in close cooperation with their Russian counterparts, and revealed a scheme for rational division of labour, work management, and logistical support of works.

Interventional radiotherapy (brachytherapy) for re-irradiation of recurrent head and neck malignancies: oncologic outcomes and morbidity.

Management of recurrent head and neck cancer (HNC) is challenging. One option in previously irradiated patients is re-irradiation using interventional radiotherapy (IRT), the modern form of brachytherapy. Re-irradiation using IRT can be delivered as an exclusive strategy for salvage or through a postoperative or perioperative approach after salvage surgery. The aim of the present study is to analyse a bicentric Italian series focusing on the use of IRT as a re-irradiation modality and assess the resulting evidence concerning oncologic outcomes and morbidity. This is a retrospective study performed in two referral centres in Italy: Policlinico Universitario Agostino Gemelli in Rome and Azienda Ospedaliera Universitaria in Sassari. All patients who had previously received a full course of external beam RT and have been re-irradiated using high-dose-rate IRT between December 2010 and June 2023 were included. Patients were retreated either by a combination of surgery and perioperative (either endocavitary or interstitial) IRT or by exclusive interstitial IRT. Thirty-four patients were included in the present series, 2 of whom underwent more than one IRT re-irradiation. Notably, no patient reported specific IRT-related toxicities. Median follow-up, excluding patients who died of HNC, was 24.5 months. Two-year local relapse-free survival was 26%, disease-specific survival 39.1%, and overall survival 36.6%. The present series is the largest reported experience of re-irradiation by IRT for HNC in Italy. The very low rate of toxicity confirms IRT as the safest re-irradiation modality. It is noteworthy to underline that IRT is a multidisciplinary strategy based on the close cooperation between surgeons and radiation oncologists during every phase, from the recommendation of treatment and implantation in the operating theatre, to its prescription and dose painting.

History of contrast enhanced ultrasound (CEUS)

The 50th year of the European Federation of Societies in Ultrasound in Medicine and Biology (EFSUMB) has been celebrated 2022 publishing articles on the history of US. Contrast enhanced ultrasound (CEUS) allows to visualize blood flow and tissue perfusion. CEUS has proven to be safe without risk of nephrotoxicity. The availability of a contrast agent (tracer) for ultrasound imaging allows for the first time a dynamic assessment of tissue perfusion (blood flow and wash-in/wash-out pattern) which is an essential part for the detection and characterisation of pathological tissue and abnormal organ function. It was an outstanding achievement of academic centers in close cooperation with EFSUMB to investigate and validate the clinical potential of this new technology for the diagnosis and monitoring of various diseases and to develop clinical guidelines based on an in-depth assessment of the existing scientific publications. An important part of the implementation of CEUS in clinical practice was the development of contrast-specific imaging modes on the ultrasound scanners (in close cooperation with the machine manufacturers), the optimization of the machine setups for contrast imaging and the education provided to clinical users in form of workshops, webinars, textbooks and scientific congresses.

Biodiversity loss impacts top-down regulation of insect herbivores across ecosystem boundaries

Biodiversity loss, as driven by anthropogenic global change, imperils biosphere intactness and integrity. Ecosystem services such as top-down regulation (or biological control; BC) are susceptible to loss of extinction-prone taxa at upper trophic levels and secondary ‘support’ species e.g., herbivores. Here, drawing upon curated open-access interaction data, we structurally analyze trophic networks centered on the fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae) and assess their robustness to species loss. Tri-partite networks link 80 BC organisms (invertebrate or microbial), 512 lepidopteran hosts and 1194 plants (including 147 cultivated crops) in the Neotropics. These comprise threatened herbaceous or woody plants and conservation flagships such as saturniid moths. Treating all interaction partners functionally equivalent, random herbivore loss exerts a respective 26 % or 108 % higher impact on top-down regulation in crop and non-crop settings than that of BC organisms (at 50 % loss). Equally, random loss of BC organisms affects herbivore regulation to a greater extent (13.8 % at 50 % loss) than herbivore loss mediates their preservation (11.4 %). Yet, under moderate biodiversity loss, (non-pest) herbivores prove highly susceptible to loss of BC organisms. Our topological approach spotlights how agriculturally-subsidized BC agents benefit vegetation restoration, while non-pest herbivores uphold biological control in on- and off-farm settings alike. Our work underlines how the on-farm usage of endemic biological control organisms can advance conservation, restoration, and agricultural sustainability imperatives. We discuss how integrative approaches and close interdisciplinary cooperation can spawn desirable outcomes for science, policy and practice.

К вопросу о зарождении и расширении социальных сетей китайских пограничных предпринимателей (на примере Хэйхэ и Благовещенска)

This article examines the stages, characteristics and influence of the social networks constructed by Chinese border traders in Heihe and Blagoveshchensk. In the early stages of business, Chinese traders can quickly and easily obtain capital, information, market and technologies with the help of their relatives or home fellows. However, in order to pursue longer-term business development and expand the Russian market, they later build more open, flexible, and heterogeneous social relationships based on economic rationality, especially expanding cross-border social networks with the Russian partners. With the increasingly close cooperation be-tween the border people of the two countries, the prosperity and stability of the border between the two coun-tries have been effectively guaranteed, and the social basis of Sino-Russian relations has become more solid.

Design and Implementation of a Physical Education Teaching and Training Mode Management System

With the advent of the smart age, all industries are undergoing revolutionary changes, and more reliable, faster, and unmanned data analysis and mining have become a prominent feature of today's industry. With basketball as an iconic sport, better data processing models will drive sports games to be played more efficiently. As an essential sport in China, basketball has more than 100 years of history. With the leap development of basketball, data analysis technology has also been widely used. The data seen in basketball games is a set of systematic data formed by professional workers through division of labor and close cooperation, classification and aggregation, and statistical analysis. In addition, based on the information on the court, spectators get a general idea of how the players perform in the Game and predict where the data will go. This article explores the significance and application of basketball game data analysis methods and shows that the analysis of basketball game data can effectively promote the development of basketball.

Experience and Prospects for the Development of Russian-Tajik Cooperation in the Field of Education

The article is devoted to the analysis of Russian-Tajik cooperation in the field of education and summarizing the results of research by Russian and foreign scientists to form a position confirming the importance of integrating the activities of educational organizations, which is a prerequisite for increasing human potential as the basic component of the socio-economic development of society. A set of measures focused on the development of the Russian-Tajik (Slavic) University was proposed, a vector of Russian-Tajik cooperation in the field of education was formed.Aim. Based on the study of many years of experience in interaction in the field of education between Russia and the Republic of Tajikistan and the features of the new economic reality, identify the most adequate forms of international cooperation, justifying the vector of their transformation.Tasks. Study the origins of the formation and analyze the reality of scientific and educational interaction between Russia and Tajikistan. Summarize and evaluate the experience of cooperation between the Russian-Tajik (Slavic) University and Russian universities. Justify the most adequate forms of international cooperation in the field of education and identify the vector of their further development in the Republic of Tajikistan.Methods. The study applied: analysis and synthesis, induction and deduction, comparisons and grouping, evolutionary and historical approaches.Results. The study showed that Russian-Tajik cooperation in the field of education has deep roots based on a long-term legislative framework, which makes it possible to really assess the existing relations between Russia and the Republic of Tajikistan and identify the prospects for their development. The generalization and adaptation of the existing experience made it possible to form reasoned positions that contribute to improving the scientific and educational level and improving the professional competencies of the trained staff, which is aimed at the socio-economic development of the two friendly countries. The study made it possible to form the following elements of scientific novelty and practical significance. Theoretical novelty consists in justifying the need to integrate the activities of educational organizations and allocating the organizational structure of an educational organization by type of organization based on knowledge as preferable in an unstable socio-economic environment. Practical significance lies in the fact that a set of measures focused on the development of RTSU is proposed and a vector for the development of educational organizations is formed in the context of their international integration.Conclusions. Scientific and educational cooperation: between Russia and Tajikistan is mutually beneficial for each of the parties. Assessment of the current situation and justification of proposals for the further development of relations between these countries made it possible to identify the vector of their transformations. For Russia and Tajikistan, the connection of education with the changes taking place in each of the countries is important. Since these changes are dynamic, continuous vocational education should play a significant role. For more effective implementation of continuing vocational education, work on career guidance is necessary, which is well combined with a dual education system that provides for close cooperation with companies, as well as the development of additional vocational education that actively responds to changes in the labor market. Positive results can be achieved only in the context of the active development of modern computer technologies, providing for interactivity, visualization, the use of case stages, mini-research, design work, as well as the possibility of hybrid learning. With this approach, the quality of comprehensive interdisciplinary research and development increases. It is recommended to form an organizational structure of an educational organization according to the type of organization based on knowledge, which is preferable in an unstable socioeconomic environment. The basis for the implementation of proposals for the further development of scientific and educational relations between Russia and Tajikistan is social partnership, as an instrument for regulating social and labor relations.

The Global Shortage of Glucagon-Like Peptide-1 Receptor Agonists

The global shortage of glucagon-like peptide-1 (GLP-1) receptor agonists, which are highly sought after as treatments for type 2 diabetes and obesity, is increasing. This deficit is attributed to the unexpected increase in demand for GLP-1 receptor agonists. This has caused significant harm to patients with type 2 diabetes mellitus who are already using GLP-1 receptor agonists for blood sugar management, weight loss, or reduction of cardiovascular risk or those who are looking to start. To address this situation, doctors need to adjust medications considering the patient condition and clinical guidelines and must provide better education on lifestyle modifications such as diet and exercise. Close cooperation between regulatory agencies and manufacturers is needed to mass-produce GLP-1 receptor agonists, as are societal efforts to prevent the trend of GLP-1 receptor agonist use as diet pills.

INSTITUTIONAL SUPPORT FOR ATTRACTING AND REALIZING INVESTMENTS IN THE ENERGY SECTOR OF UKRAINE

The article analyzes the issues of adequateness of the institutional support for attracting and realizing investments in the energy sector of Ukraine to the current realities in which the country finds itself. The article emphasizes that public-private partnership is the basis for further attraction and realization of investments in the energy sector. The article highlights several issues such as attracting investment in the energy sector of Ukraine, and public-private partnership in the energy sector and identifies the ways to overcome them.The necessity of improving the legal framework in the field of public-private partnership; development of institutional infrastructure supporting public-private partnership; providing guarantees for protecting the interests of all parties in the public-private partnership throughout the entire life cycle of the project is substantiated.It is concluded that attracting and injecting investments in the energy sector is possible only in close cooperation with large private businesses by implementing elements and mechanisms of public-private partnership in the sector. It’s the only way that the energy sector of Ukraine will be able to adapt to modern challenges to ensure its long-term sustainable development.

위탁 어린이집 원장의 현실과 대안 모색

The purpose of this study is to examine the problems of foster daycare centers and to suggest alternatives. Based on the importance of infant education, it was seen that the number of national and public daycare centers and workplace daycare centers increased during reservation integration. There are several problems in operating national, public, and workplace daycare centers, and it was found that there were problems related to reconsignment and instability of the director's status. The problems of the entrusted daycare center and their solutions were presented in two ways. First, it is the instability of the status that comes from the consignment screening process. In order to solve these problems, the director of daycare centers should be recognized as a worker. In addition, national and public daycare centers need to operate by rotating the heads of national and public daycare centers in the region rather than re-entrustment screening, and implement a circular job system so that they can demonstrate their skills. Second, close cooperation with the operating entities related to consignment is required. Related entities are also involved in the operation of daycare centers due to a lack of understanding of childcare work, market economy logic, and corporate logic. In order to solve this problem, various subjects and managers related to daycare centers need to be educated to enhance the importance of childcare work and understanding of the childcare field. Institutional managers and parents need to recognize that daycare centers are not institutions operated by employee welfare, but are specialized childcare institutions that do their best to grow and raise children. It is necessary to change the perception of the mindset to respect and cooperate with childcare teachers, and the subject of the establishment of daycare centers and the trustee should provide parental education in which daycare centers can be recognized as one institution.

Sweden's quest for shelter: ‘Nonalignment' and NATO membership

AbstractThis paper posits that, contrary to conventional wisdom, Sweden's decision to join the North Atlantic Treaty Organisation (NATO) and end its official policy of ‘nonalignment’ is neither very surprising nor radical in nature. Utilising the shelter theory framework, we examine the Swedish case to shed a new light on the economic, societal and political shelter‐seeking policy choices that led to Stockholm's NATO application in May of 2022. The analysis finds that Sweden's established strategy of seeking shelter from Western powers eventually induced and facilitated close military cooperation with NATO—ultimately leading to accession on 7 March 2024. The decision to join the Alliance should, therefore, be understood as a culmination, building on a historically flexible approach to neutrality and previously established shelter arrangements that were deemed in 2022, after Russia's full‐scale invasion of Ukraine and subsequent developments in Finland, to be no longer sufficient in deterring or responding to new threat dynamics. The case indicates that shelter theory accurately captures the foreign policy strategy of a small neutral and later nonaligned state. However, analysing Sweden's move towards NATO within the given framework also presents an opportunity for theory development; specifically, the theory ought to more meticulously examine three small‐state shelter‐seeking features, namely, how societal and economic shelter relations may precede and, therefore, affect political shelter strategies (or vice versa), the role of ‘critical junctures’ in the theory; and finally, how small states may be affected by each other's shelter‐seeking strategies.

Community-Based Psychiatric Care Provision in Hungary: Trends and Steps towards Progress

Psychiatric care has undergone several cycles of profound changes in the past centuries all over the world. In Hungary, community-based outpatient care has been showing signs of evolution since the 1950s. Initially, the system centered on assertive outreach and family involvement, especially for those with serious mental health problems. Such services remain available throughout the country, but the emphasis in the past decades has shifted towards mass care provision. In many places, community-based services are no longer provided, and where they are the approach is biomedical and less asuming of recovery. In other centers, the services provided are conceived with the eventuality of rehabilitation in mind and in close cooperation with community-based care providers.
 Community-based services providers, as part of the social fabric, offer as many psychiatric and rehabilitation services as possible for those with mental disorders within their communities. The main objective of community-based care is to achieve community re-integration and recovery from mental disorders. Today in Hungary, deinstitutionalisation and the introduction of community-based psychiatric care have been adopted even by large inpatient institutions. The replacement of institutional bed space and the provision of subsidised housing further underscore the importance of community-based psychiatric care provision. There is the opinion that, as a further course of development, the emphasis needs to now shift towards the nurturing of a community of experienced experts and creastion of user-led programs. In this new paradigm, the ability of a person with a mental disorder to make decisions and the bolstering of that ability are seen as vital. In order to achieve these objectives, it is essential that health and social seervices professionals cooperate. Hands-on experience is key in the provision and development of such services.

"Has Anyone Been There Now?": An Interview Study on the Support Experiences and Unmet Needs of Informal Long-Distance Caregivers for Patients at the End of Life.

In the German context, research is lacking on the support experiences and unmet needs of informal caregivers in end-of-life situations who are geographically distanced from their ill relatives. The current study aimed at deepening our understanding of the specific end-of-life support experiences and needs of informal long-distance caregivers. The study employed an explorative design, applying qualitative interviews. Thirty-three long-distance family caregivers participated in the study (December 2021-October 2022). The results showed that long-distance caregivers relied on close exchange and cooperation with local family and non-kin caregivers. They also expressed the wish to be considered more proactively by professional caregivers, with respect to their specific geographic situations. They further recommended that local care networks be built to support patients. Hypotheses were deduced from long-distance caregivers' recommendations for support interventions. The results may be useful for the development of an online information resource for long-distance caregivers in end-of-life situations.

Antifreeze protein-based ultrastretchable and highly sensitive hydrogel for human-machine interaction

Intelligent and convenient human–computer interfaces realize efficient and close cooperation between people and the digital world. As windows of human–machine interaction (HMI), sensors directly determine the ability and quality of acquired signals and the utilization potential of HMI systems. However, it still remains challenging to develop antifreeze hydrogel sensors with freeze-resistant properties while avoiding the loss of other properties as much as possible to achieve stable HMI applications in low-temperature environments. Here, we present an Agar/PAAm dual-network hydrogel (Na+-Agar/PAAm-AFP) doped with both antifreeze protein (AFP) and sodium chloride (NaCl), which exhibits excellent antifreeze capability (−20 °C). The hydrogel integrates transparency (>90%), ultra stretchability (up to 2100%), good adhesion properties to metal, glass, and plastic, high electrical conductivity (3.41 S m−1), high sensitivity (GF = 10.23), and non-irritating to the skin. The hydrogel can be used for monitoring daily activities and glove-based HMI systems for intelligent control. In addition, based on this hydrogel, we have successfully developed an interactive system for real-time information transfer over long distances. It is expected to provide better health management monitoring in several fields and also help to advance the development of innovative and IoT technologies.

Research on the path to enhance the cultural communication literacy of Thai international Chinese language teachers

With the rapid development of global integration, new requirements have been put forward for the content of communication and cooperation among countries. Since the 1990s, China's comprehensive strength has continued to develop rapidly and has become an indispensable and important country in the global development process. With China's increasing international status and close cooperation with countries around the world in multiple fields, each country has a strong demand for learning Chinese, which has prompted China's Chinese language and culture to enter a new stage of high-quality development. Language is a bridge of communication that can promote the integration and development of international culture, industry, and other aspects. International Chinese language teachers play a particularly important role in the dissemination of Chinese language and literature. Therefore, it is necessary to develop a standardized framework and model for cultivating the ability elements of international Chinese language teachers based on guidance and goals, in order to promote sustainable development. This study uses literature review, interview methods, and mathematical statistics to investigate some international Chinese language teachers who have traveled from China to Thailand. The PDCA cycle theory is used to establish a development path centered on "current situation analysis, innovation path, path evaluation, and continuous improvement", exploring the difficulties and difficulties in improving the cultural communication literacy ability of Thai international Chinese language teachers, Targeted optimization and development paths should be proposed: (1) Reasonable goals and development ideas for cultivating the ability elements of international Chinese language teachers should be formulated based on the actual situation of Thai Chinese language learning, exploring deep internal motivation and logical relationships, and improving the framework for cultivating ability elements based on the elements of communication. (2) In the specific implementation process, specific indicators for cultivating ability elements should be clearly defined to strengthen standardization. Targeted training should be conducted based on relevant indicators. (3) Targeted ability element training standards should be developed for Chinese language teachers based on the actual environment, needs, and theoretical foundation of international communication in Thai Chinese language learning. Fourthly, explore diversified cultural communication methods and development path choices, improve the comprehensive ability of Thai international Chinese language around the elements of global communication, and continuously optimize the curriculum system and teaching content. (4) We should improve the evaluation and feedback system, establish clear management systems and development plans for each stage, and promote excellent culture and concepts in a healthy manner. In the specific implementation process, being good at identifying and proposing problems, and combining practical experience to fully solve problems, can help promote deep development.